Altered Th17/Treg balance and therapeutic targeting of RORγ in primary focal hyperhidrosis
PFH is associated with a Th17/Treg immune imbalance. SR2211 alleviated hyperhidrosis and Th17-related inflammation in mice, highlighting the potential of targeting the RORγ-Th17 axis as a therapeutic strategy for PFH.
Authors
- Yuanrong Tu (ORCID: https://orcid.org/0009-0005-1449-4675)
- Quan Du (ORCID: https://orcid.org/0000-0002-6932-5183)
- Jianbo Lin (ORCID: https://orcid.org/0000-0002-7484-6143)
- Lin Min
- Jian-Feng Chen
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1656632
- Primary Topic
- Sympathectomy and Hyperhidrosis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Innovation Project of Fujian Province