Proteins linked to type II interferon response in Sjögren’s disease: novel indicators for disease monitoring and predicting treatment response to leflunomide and hydroxychloroquine combination therapy
These data support a significant role for a type II IFN-associated immune response in SjD pathogenesis, which is targeted by LEF/HCQ. Proteins associated with type II IFN-driven immune responses hold potential to monitor disease activity and predict treatment response.
Authors
- Valentin Baloche (ORCID: https://orcid.org/0000-0001-9471-0043)
- Joël A. G. van Roon (ORCID: https://orcid.org/0009-0009-5571-2324)
- Sofie L. M. Blokland (ORCID: https://orcid.org/0000-0002-2506-2422)
- Helen L. Leavis (ORCID: https://orcid.org/0000-0001-8720-3684)
- W. Y. Wong
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Center for Translational Molecular Medicine (NL)
- Ziekenhuis Groep Twente (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1566377
- Citations
- 1
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 1.16