Comprehensive analysis of single-cell and bulk transcriptomes reveals key B-cell genes and immune microenvironment regulation in bladder cancer
Using a combination of transcriptomic and experimental validation at single-cell and batch levels, this study provides insights into the key gene signatures of B cells from patients with bladder cancer and their roles in regulating the tumor immune microenvironment, providing new biomarkers and potential therapeutic targets for predicting patient' prognosis and immunotherapy response.
Authors
- Zi‐Tao Zhong (ORCID: https://orcid.org/0000-0003-4232-7370)
- Yunpeng He (ORCID: https://orcid.org/0000-0001-9672-7615)
- Lijun Wang (ORCID: https://orcid.org/0000-0001-6145-1997)
- Lin Ye (ORCID: https://orcid.org/0009-0009-7935-6547)
- Yuan Zhao (ORCID: https://orcid.org/0000-0002-2940-1786)
- Juan Yang (ORCID: https://orcid.org/0000-0002-4829-2888)
- Tao Bo (ORCID: https://orcid.org/0000-0001-9083-4639)
- Jian Wu (ORCID: https://orcid.org/0009-0007-9762-2517)
- Zhangxiao Xu
- Yiran Ma
Institutions
- Kunming University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1600254
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01