RNA m <sup>1</sup> A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing <i>ONECUT2</i> mRNA stability and is a potential therapeutic target
Our study unveiled the tumor-promoting role of TRMT61A in CRC via the m<sup>1</sup>A-ONECUT2-SOS1-MAPK/ERK pathway. Targeting TRMT61A showed promise as a therapeutic strategy for treating CRC.
Authors
- Hao Su (ORCID: https://orcid.org/0000-0002-7621-8730)
- Matthew T.V. Chan (ORCID: https://orcid.org/0000-0002-3574-7855)
- Haiyun Shang
- Zongwei Cai (ORCID: https://orcid.org/0000-0002-8724-7684)
- Jiabin Wu (ORCID: https://orcid.org/0000-0002-7380-7038)
- Dan Huang (ORCID: https://orcid.org/0000-0003-3022-5772)
- Na Qin (ORCID: https://orcid.org/0000-0001-6878-9464)
- Huarong Chen (ORCID: https://orcid.org/0000-0003-2192-1864)
- Fenfen Ji (ORCID: https://orcid.org/0000-0002-2265-7607)
- Yifei Wang (ORCID: https://orcid.org/0000-0002-2073-2837)
- Hongyan Chen (ORCID: https://orcid.org/0000-0003-4924-6100)
- Xiaoting Zhang (ORCID: https://orcid.org/0000-0002-7555-9162)
- Qing Li (ORCID: https://orcid.org/0000-0002-0169-8098)
- Jun Qing Yu (ORCID: https://orcid.org/0000-0001-5008-2153)
- Weixin Liu (ORCID: https://orcid.org/0000-0002-1650-0371)
- C.C. Wong (ORCID: https://orcid.org/0009-0001-6167-9403)
- Jing Ren (ORCID: https://orcid.org/0009-0007-9041-9479)
- William Ka Kei Wu (ORCID: https://orcid.org/0000-0002-4651-677X)
Institutions
- Hong Kong Baptist University (HK)
- Chinese University of Hong Kong (HK)
- Chinese University of Hong Kong, Shenzhen (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1002/cac2.70070
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Chinese University of Hong Kong