Alkaloid-driven multi-target synergy of Tripterygium wilfordii polyglycosides overcomes cisplatin resistance in ovarian cancer by coordinated inhibition of PTPN11/EGFR/JAK signaling
Our findings suggest that alkaloids in TWP may exert multi-target synergy to disrupt key survival pathways driving cisplatin resistance in ovarian cancer. These mechanistic insights not only rationalize its observed anti-tumor activity but also support its potential clinical repurposing from an approved anti-inflammatory drug to an oncology therapeutic.
Authors
- Minxin Zhang (ORCID: https://orcid.org/0000-0002-2154-9823)
- Ying Wang (ORCID: https://orcid.org/0000-0003-4550-3413)
- Bing Lin
Institutions
- Fujian Medical University (CN)
- 117th Hospital of People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fphar.2025.1686526
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00