Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways
Artemisinin exerts significant neuroprotective and antidepressant-like effects through multiple molecular and cellular mechanisms, highlighting its potential as a novel therapeutic agent for depression.
Authors
- Jinfeng Xie
- Yizhou Jiang (ORCID: https://orcid.org/0000-0002-6537-9766)
- Henning Ulrich (ORCID: https://orcid.org/0000-0002-2114-3815)
- Ruohong Lin
- Song Liu (ORCID: https://orcid.org/0000-0002-7432-5241)
- Haitao Wang (ORCID: https://orcid.org/0000-0002-5972-1393)
- Wenhua Zheng (ORCID: https://orcid.org/0000-0001-9014-0055)
- Zhiwei Zhou (ORCID: https://orcid.org/0000-0002-0391-6511)
Institutions
- Universidade de São Paulo (BR)
- Guangdong Pharmaceutical University (CN)
- University of Macau (MO)
- National Medical Products Administration (CN)
- Gree (China) (CN)
- Southern Medical University (CN)
- City University of Macau (MO)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fphar.2025.1642167
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- United Mitochondrial Disease Foundation
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- National Natural Science Foundation of China
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade de Macau
- Guangdong Science and Technology Department