Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats
Sini San modulates the gut-brain axis by inhibiting the NLRP3 inflammasome, thereby alleviating CUMS-induced inflammation and gut microbiota dysbiosis in rats. This effect may further contribute to the improvement of depressive symptoms via regulation of the BDNF/TrkB/PI3K/AKT signaling pathway.
Authors
- Xi He (ORCID: https://orcid.org/0000-0002-8093-7981)
- Shusheng Yang
- Hui-yue Wang
- Jing Bai (ORCID: https://orcid.org/0000-0002-0797-4209)
- Lin Li (ORCID: https://orcid.org/0000-0002-3821-7147)
- Zhen-Jie Han
- Xuejiao Liu (ORCID: https://orcid.org/0009-0005-7045-6323)
- Yanjun Duan (ORCID: https://orcid.org/0000-0002-1351-7397)
- Jia-Wei Zeng (ORCID: https://orcid.org/0009-0002-6020-2686)
Institutions
- Hubei University of Chinese Medicine (CN)
- Jingchu University of Technology (CN)
- Wuhan Red Cross Hospital (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fpsyt.2025.1628634
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province
- China Postdoctoral Science Foundation