HPLC–UV-Guided Discovery of Eurotamines A–F: Six Pairs of Isoquinoline Derivative Enantiomers from Marine-Derived Fungus <i>Eurotium</i> sp. SCSIO F452
Six pairs of unprecedented isoquinoline derivative enantiomers were obtained by HPLC-UV-guided isolation from the salicylaldehyde-producing marine fungus <i>Eurotium</i> sp. SCSIO F452. Their structures were characterized by spectroscopic analyses, X-ray diffraction, and electronic circular dichroism calculations. They represent unusual groups of oxidized, prenylated benzopyridines with a C<sub>7</sub> side chain cyclized in different patterns, generating 6/6/5/6 (<b>1</b>-<b>3</b>), 6/6 (<b>4</b> and <b>5</b>), and 6/6/6 (<b>6</b>) ring systems. Selected isomers exhibited weak cytotoxic activities against a panel of cancer cell lines.
Authors
- Yuchan Chen
- Fa‐Zuo Wang (ORCID: https://orcid.org/0000-0003-4961-6669)
- Xinpeng Tian (ORCID: https://orcid.org/0000-0001-5871-0062)
- Weimao Zhong (ORCID: https://orcid.org/0000-0002-1358-4944)
- István Molnár
- Xiaoyi Wei (ORCID: https://orcid.org/0000-0002-4053-6999)
- Yi-Hao Che (ORCID: https://orcid.org/0000-0002-5602-0268)
- Weimin Zhang (ORCID: https://orcid.org/0000-0002-8836-1438)
- Junfeng Wang (ORCID: https://orcid.org/0000-0001-8914-5174)
- Si Zhang (ORCID: https://orcid.org/0000-0002-5682-4995)
- Qi Zeng (ORCID: https://orcid.org/0000-0002-3563-0569)
- Hao Yin (ORCID: https://orcid.org/0009-0009-0754-811X)
- Lin Wang (ORCID: https://orcid.org/0000-0002-1588-588X)
Institutions
- Chinese Academy of Sciences (CN)
- Beijing Botanical Garden (CN)
- Institute of Oceanology (CN)
- Guangdong Academy of Sciences (CN)
- South China Sea Institute Of Oceanology (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
- South China Botanical Garden (CN)
- Institute of Microbiology (CN)
- University of Chinese Academy of Sciences (CN)
- VTT Technical Research Centre of Finland (FI)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1021/acs.orglett.5c03641
- Citations
- 1
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.94