Construction of pathogenic <i>Sec16a</i> mutation mouse model using <scp>CRISPR</scp>/Cas9
The Sec16aL1551V/L1551V mouse model developed in this study providing a powerful tool for better understanding of the pathogenic mechanisms of Sec16a gene mutations in brain dysfunction diseases.
Authors
- Liangcai Gao (ORCID: https://orcid.org/0000-0001-9444-1568)
- Yuting Guan (ORCID: https://orcid.org/0000-0003-1866-270X)
- Ming Xu (ORCID: https://orcid.org/0000-0002-4922-3809)
- Zhiyang Zeng (ORCID: https://orcid.org/0000-0002-0235-1352)
- Yaqiang Hu
- Dali Li (ORCID: https://orcid.org/0000-0002-0679-8477)
- Shuming Yin
Institutions
- Xian Central Hospital (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1002/ame2.70082
- Citations
- 1
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- East China Normal University
- National Key Research and Development Program of China