Neuropeptide-Mediated Crosstalk between Subchondral Bone and Articular Cartilage in Ankle Osteoarthritis: A Cross-Sectional Histologic Study of 17 Ankles
CGRP and SP expression in the subchondral bone was closely linked to structural bone changes and cartilage degradation in ankle OA. Their early expression and association with osteoclast activity support a potential role in OA pathogenesis; however, causation cannot be inferred from this cross-sectional study.
Authors
- Nobuo Adachi (ORCID: https://orcid.org/0000-0002-5570-3729)
- Yasunari Ikuta (ORCID: https://orcid.org/0000-0002-8419-9154)
- Tomoyuki Nakasa (ORCID: https://orcid.org/0000-0002-6267-3556)
- Dan Moriwaki
- Satoru Sakurai
- Saori Ishibashi
- Taro Chujo
Institutions
- Hiroshima University (JP)
Publication Details
- Journal
- Foot & Ankle International
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1177/10711007251372141
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00