Oral gepotidacin for the treatment of uncomplicated urinary tract infection in Japanese female patients: a randomized, active reference, double-blind, double-dummy, Phase 3 trial (EAGLE-J)
Gepotidacin therapeutic success at test-of-cure was consistent between EAGLE-J and EAGLE-2/-3. Gepotidacin has potential as a valuable oral treatment option for uUTI in Japan. No new safety signals were identified.
Authors
- Shinji Iwata (ORCID: https://orcid.org/0009-0005-3956-1539)
- Hiroko Kusuyama
- Ken-ichi Suyama
- Fumio Manabe
- Jiro Hashimoto
- Masaharu Nanri
- Motoshi Kawahara
- Kenji Sugimoto (ORCID: https://orcid.org/0000-0003-3735-9343)
- Shizuo Kayama (ORCID: https://orcid.org/0000-0003-2420-3542)
- Tatsuya Ogishima
- Akinori Nimura
- Yasuto Muromiya
- Rudrani Banerjee (ORCID: https://orcid.org/0009-0004-8268-7113)
- Susan Mozzicato
- Mirei Kamei
- Shintaro Ura
- Hideo Takashima
- Nicole E. Scangarella-Oman (ORCID: https://orcid.org/0000-0003-4211-8261)
- Mototaka Hayashi
- Mori Masaru
- Shingo Yamamoto (ORCID: https://orcid.org/0000-0001-6032-0557)
- Tomokazu Umeyama (ORCID: https://orcid.org/0000-0003-4145-5784)
- H Kameoka
- Hiroshi IGARASHI (ORCID: https://orcid.org/0000-0001-6289-2452)
- Kenji Fujii (ORCID: https://orcid.org/0000-0001-6603-6362)
- Kazuyuki Sagiyama
- Yuki Sekiguchi
- Yoshikatsu Tanahashi
- Yoko Hayami
- Marcela Ramírez
- Toshiyuki Kamijo
- Takatoshi Konishi
- Kiyoshi Nakamura
- Ting-Wen Huang
- Yoko Kayama
- Takao Maenaka
Institutions
- Girls Incorporated (US)
- Kaneka (United States) (US)
- University of Tsukuba (JP)
- Pride Foundation (US)
- Umma University (KE)
- Tsuchiura Kyodo General Hospital (JP)
- GlaxoSmithKline (India) (IN)
- Kunitachi Sakura Hospital (JP)
- Iwata City Hospital (JP)
- Hayashi Eye Hospital (JP)
- Akebono Clinic (JP)
- GlaxoSmithKline (United States) (US)
- General Hospital of Drama (GR)
- GlaxoSmithKline (Japan) (JP)
- SOUSEIKAI Global Clinical Research Center (JP)
- Kawamura Hospital (JP)
- Osaka Nishi Clinic (JP)
- Ono Clinic (JP)
- Lake Tanganyika Authority (BI)
- Japanese Urological Association (JP)
- Shinmatsudo Central General Hospital (JP)
- Minamiaoyama Eye Clinic (JP)
- Kamuli General Hospital (UG)
- Kishokai Medical Corporation (JP)
- Kyoto University of Advanced Science (JP)
- Hyogo University (JP)
- Seijo University (JP)
Publication Details
- Journal
- Journal of Infection and Chemotherapy
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1016/j.jiac.2025.102829
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00