Reclassifying pediatric NAFLD using the steatotic liver disease framework: A multicenter retrospective study from the NASH CRN
Most children with NAFLD met MASLD criteria, but nearly 1 in 6 were reclassified based on alcohol use or medication exposure. These findings highlight the need for a systematic diagnostic approach accounting for metabolic risk factors, alcohol use, and medication-related liver injury.
Authors
- Krupa R. Mysore (ORCID: https://orcid.org/0000-0001-9890-5518)
- Miriam B. Vos (ORCID: https://orcid.org/0000-0002-0817-7068)
- Ajay K. Jain (ORCID: https://orcid.org/0000-0002-9420-5722)
- Stavra A. Xanthakos (ORCID: https://orcid.org/0000-0001-9179-005X)
- Jean Pappas Molleston (ORCID: https://orcid.org/0000-0002-8708-0298)
- Kimberly P. Newton (ORCID: https://orcid.org/0009-0000-9533-8685)
- Mark Fishbein (ORCID: https://orcid.org/0000-0002-3597-3748)
- Niviann Blondet (ORCID: https://orcid.org/0000-0001-5122-0706)
- TH Lam (ORCID: https://orcid.org/0000-0002-2033-9971)
- Sheila L. Noon (ORCID: https://orcid.org/0000-0002-8572-167X)
- Cynthia A. Behling (ORCID: https://orcid.org/0000-0001-7016-2636)
- Laura Wilson (ORCID: https://orcid.org/0000-0002-6294-4504)
- Jeffrey B. Schwimmer (ORCID: https://orcid.org/0000-0001-8538-2877)
- Katherine P. Yates (ORCID: https://orcid.org/0000-0001-6138-2194)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Lurie Children's Hospital (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of Missouri–St. Louis (US)
- Riley Hospital for Children (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Seattle Children's Hospital (US)
- Texas Children's Hospital (US)
- Saint Louis University (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1097/hep.0000000000001577
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35