The effect of Dexmedetomidine on remote organ injury in the lung in rats with pancreatic ischemia reperfusion model
Dexmedetomidine significantly reduced oxidative stress, alleviated alveolar structural damage, and decreased the total injury score in lung tissue in a pancreatic IR model. These findings suggest that dexmedetomidine may be a potential pharmacological agent for preventing pulmonary complications that can arise following pancreatic surgery or severe pancreatitis.
Authors
- Hasan Bostancı (ORCID: https://orcid.org/0000-0002-3160-1488)
- Şaban Cem Sezen (ORCID: https://orcid.org/0000-0003-3996-7692)
- Gülay Kip (ORCID: https://orcid.org/0000-0001-5242-5332)
- Selin Erel (ORCID: https://orcid.org/0000-0002-6040-9815)
- Mustafa Arslan (ORCID: https://orcid.org/0000-0003-4882-5063)
- Ayşegül Küçük (ORCID: https://orcid.org/0000-0001-9316-9574)
- Fatma Er (ORCID: https://orcid.org/0000-0003-3008-1764)
- Mustafa Kavutçu (ORCID: https://orcid.org/0000-0002-5135-8067)
- Muharrem Atlı
- Kürşat Dіkmen
- Feyza Aktepe
Institutions
- Kütahya Dumlupınar Üniversitesi (TR)
- Kutahya Saglik Bilimleri Universitesi
- Kırıkkale University (TR)
- Gazi University (TR)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12871-025-03373-8
- Citations
- 1
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.47