Synthesis of triazolo- and tetrazolo-fused 1,4-benzodiazepines via one-pot Ugi–azide and Cu-free click reactions
A one-pot Ugi-azide reaction followed by intramolecular Cu-free azide-alkyne cycloaddition generates a polycyclic scaffold <b>7</b> bearing polycyclic triazole, tetrazole, and benzodiazepine rings. This method could be extended for obtaining a more complicated scaffold <b>8</b> containing a piperazinone ring.
Authors
- Jiawei Niu
- Shenghu Yan
- Sai Zhang (ORCID: https://orcid.org/0009-0005-2457-5364)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-6097-2763)
- Wen Shao (ORCID: https://orcid.org/0000-0002-2922-4118)
- Zhiwei Gao (ORCID: https://orcid.org/0009-0003-7700-304X)
- Xiaoming Ma (ORCID: https://orcid.org/0000-0003-1358-428X)
Institutions
- University of Massachusetts Boston (US)
- Changzhou University (CN)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3762/bjoc.21.167
- Citations
- 1
- Primary Topic
- Synthesis of Tetrazole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.94