Urinary tract infection and continuation of sodium-glucose cotransporter-2 inhibitors in diabetic patients
New-onset UTI was associated with an increased risk of cardiovascular and renal events in patients with T2DM prescribed SGLT2 inhibitors. Discontinuing SGLT2 inhibitors after a UTI was linked to a higher risk of cardiovascular and renal outcomes but was not associated with fewer recurrent UTI.
Authors
- Christopher Tze‐Wei Tsang (ORCID: https://orcid.org/0000-0003-3394-6604)
- Chi‐Ho Lee (ORCID: https://orcid.org/0000-0002-7569-409X)
- Ran Guo (ORCID: https://orcid.org/0000-0003-0654-6314)
- Yap‐Hang Chan (ORCID: https://orcid.org/0000-0001-5384-8468)
- Mei‐Zhen Wu
- Lin Liu (ORCID: https://orcid.org/0000-0001-9881-6830)
- Chanchal Chandramouli (ORCID: https://orcid.org/0000-0001-8256-902X)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Jingnan Zhang (ORCID: https://orcid.org/0000-0002-4865-5212)
- Wenli Gu (ORCID: https://orcid.org/0000-0001-7162-6017)
- Andrew Tung
- Jiayi Huang (ORCID: https://orcid.org/0000-0002-5153-506X)
- Ching-Yan Zhu
- Kai Hang Yiu (ORCID: https://orcid.org/0000-0003-2145-3108)
- Yik‐Ming Hung
- Yi-Kei Tse
- Qing-Wen Ren
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Queen Mary Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Duke-NUS Medical School (SG)
- University of Hong Kong - Shenzhen Hospital (CN)
- National Heart Centre Singapore (SG)
- University of Hong Kong (HK)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1093/eurheartj/ehaf788
- Citations
- 4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Hospital Authority
- Sanming Project of Medicine in Shenzhen