The Neurocircuitry of Cannabis Cue Reactivity in Cannabis Use Disorder: A Functional Neuroimaging Study
Exposure to cannabis cues can elicit greater activity within salience evaluation/attention, motivation, and disinhibition pathways of addiction neurocircuitry in people with moderate-to-severe CUD, consistent with prominent neuroscientific theories of addiction and findings with other substances. Interventions that can suppress brain activity in salience and attention circuits during cannabis cue reactivity may help reduce craving and subsequent use.
Authors
- Diny Thomson (ORCID: https://orcid.org/0009-0004-2327-2372)
- Arush Honnedevasthana Arun (ORCID: https://orcid.org/0000-0001-6096-2445)
- Chao Suo (ORCID: https://orcid.org/0000-0002-9358-6690)
- Janna Cousijn (ORCID: https://orcid.org/0000-0002-7699-2582)
- Izelle Labuschagne (ORCID: https://orcid.org/0000-0002-1590-0947)
- Hannah Sehl
- Govinda Poudel (ORCID: https://orcid.org/0000-0002-0043-7531)
- Adam Clemente
- Eugene McTavish
- Hannah Thomson (ORCID: https://orcid.org/0000-0002-7220-1624)
- Lisa‐Marie Greenwood (ORCID: https://orcid.org/0000-0002-0762-1921)
- Alexandra Gaillard (ORCID: https://orcid.org/0000-0002-4852-0238)
- Emillie Beyer (ORCID: https://orcid.org/0009-0005-2323-4111)
- Gill Terrett (ORCID: https://orcid.org/0000-0003-2500-6428)
- Peter G. Rendell (ORCID: https://orcid.org/0000-0002-4829-4322)
- Victoria Manning (ORCID: https://orcid.org/0000-0003-3908-5980)
- Valentina Lorenzetti (ORCID: https://orcid.org/0000-0001-8730-8857)
- Marianna Quinones‐Valera
Institutions
- Australian National University (AU)
- Allen Institute for Brain Science (US)
- The University of Queensland (AU)
- Eastern Health (AU)
- IVO Addiction Research Institute (NL)
- Monash University (AU)
- Swinburne University of Technology (AU)
- Australian Catholic University (AU)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100638
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00