Tertiary Lymphoid Structures Are Associated with Favorable Clinical Outcomes and Negatively Correlated with Cancer-Associated Fibroblasts in Esophageal Cancer
TLSs enhance antitumor immunity via macrophages and plasma cells and can be a valuable prognostic indicator in patients undergoing surgery for esophageal cancer. Targeting CAFs may prove to be a promising therapeutic strategy to enhance tumor-immunity-related TLSs.
Authors
- Yasushige Takeda
- Hiroshi Tazawa (ORCID: https://orcid.org/0000-0003-4658-1050)
- Seitaro Nishimura
- Shunsuke Tanabe
- Satoru Kikuchi (ORCID: https://orcid.org/0000-0002-7671-0696)
- Tomoyoshi Kunitomo (ORCID: https://orcid.org/0009-0009-7065-0440)
- Yasuhiro Shirakawa (ORCID: https://orcid.org/0000-0003-4698-5119)
- Toshiyoshi Fujiwara (ORCID: https://orcid.org/0000-0002-5377-6051)
- Masaaki Akai (ORCID: https://orcid.org/0000-0002-0742-7272)
- Kento Kawasaki (ORCID: https://orcid.org/0009-0006-7547-5926)
- Noriyuki Nishiwaki (ORCID: https://orcid.org/0000-0003-4048-3003)
- Kazuhiro Noma (ORCID: https://orcid.org/0000-0002-5584-3908)
- Toshiaki Ohara (ORCID: https://orcid.org/0000-0003-1557-1589)
- Hijiri Matsumoto
- Naoaki Maeda
- Takahashi Tatsuya
Institutions
- Okayama University (JP)
- Okayama University Hospital (JP)
- Hiroshima City Asa Citizens Hospital (JP)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3390/cancers17203351
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00