Integrated metabolomic and transcriptomic analysis identifies adipogenic differentiation of mesenchymal stem cells as a driver of chemoresistance in acute myeloid leukemia
This work demonstrates that the adipogenically differentiated MSCs enhance the survival and chemoresistance of AML cells by modulating metabolic and signaling pathways. It provides integrated insights into the microenvironment-driven mechanisms of AML drug resistance and presents potential therapeutic targets to enhance treatment efficacy.
Authors
- Yi Hong (ORCID: https://orcid.org/0000-0002-5846-2596)
- Rong Hu (ORCID: https://orcid.org/0000-0001-8691-9509)
- Zhipeng Pan (ORCID: https://orcid.org/0000-0002-6630-6163)
- Lixia Kang
- Yanyu Duan (ORCID: https://orcid.org/0000-0001-6603-3508)
- Xiaofan Jia
- Zhengwei Duan (ORCID: https://orcid.org/0000-0003-3571-2051)
- Shaoren Deng (ORCID: https://orcid.org/0000-0001-7594-5015)
- Ling Chen (ORCID: https://orcid.org/0000-0003-1485-1626)
- Dandan Li (ORCID: https://orcid.org/0000-0001-8301-830X)
- Chen Yang (ORCID: https://orcid.org/0000-0002-9043-144X)
- Pengfei Guo (ORCID: https://orcid.org/0009-0009-1989-2508)
- Mengyao Wang (ORCID: https://orcid.org/0000-0002-2681-3873)
Institutions
- Fujian Medical University (CN)
- Xiamen University (CN)
- Sir Run Run Shaw Hospital (CN)
- Fuzhou Second Hospital (CN)
- Union Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s13046-025-03550-0
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province
- Xiamen University
- Fujian Medical University