AT1R autoantibody impedes fetal hepatic glycogen synthesis by inhibiting PI3K/AKT signaling pathway during late gestation
Our study identifies AT1-AA as a unique maternal factor that selectively impairs fetal hepatic glycogen storage via AT1R-mediated suppression of PI3K/AKT pathway.
Authors
- Xiang Cheng (ORCID: https://orcid.org/0000-0002-6287-3128)
- Suli Zhang (ORCID: https://orcid.org/0000-0002-9711-9387)
- Lina Bai (ORCID: https://orcid.org/0000-0003-0107-643X)
- Chunyu He (ORCID: https://orcid.org/0000-0003-4281-8655)
- Huirong Liu (ORCID: https://orcid.org/0009-0004-0974-8311)
- Jingwei Bian
- Wang Wang (ORCID: https://orcid.org/0000-0001-9093-412X)
- Pengli Wang
- Mingming Yue
Institutions
- Union Hospital (HK)
- Capital Medical University (CN)
- Peking University (CN)
- Peking University First Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12967-025-07147-1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China