Author Profile: Shrabani Halder

Our research focused on centrosomes biology, a topic under the field of cell biology. Cytoskeleton is a reputed journal of cell biology focusing on cytoskeletal dynamics and organelle biology, with a great mix of renowned and mid-career scientists in the editorial panel, therefore assuring valuable critical suggestions. It provides a suitable platform for higher relevance in citation for a wide range of researchers in the field of cell biology. Two other aspects we also considered while submitting this study. First one was the communication timeframe for editorial decisions and the review, which is usually professionally dealt with Wiley publication group. The second important aspect was to have the subscription mode of publishing with ‘no publication fee’. We are from a small university with limited funding for research, which does not provide the flexibility to pay the publication fees/APCs in most reputed journals. We really appreciate the journal's policy to offer the choice of subscription and open access, instead of only ‘open-access’ with APCs. Our lab is investigating various aspects of molecular regulation of centriole assembly and ciliogenesis, with a broad focus on tumorigenesis and ciliopathies. In one hand, we are keen to identify mechanisms of excess centriole formation, which are often seen in human cancers, and to develop strategies to inhibit this pathway by clinical means. On the other hand, we are studying how novel pathways regulated by mitochondrial porins or cytoskeletal rearrangement affect primary cilia assembly and disassembly, and primary cilia mediated signalling in mammalian cells. One of my favourite topics has been exploring the mechanism of centriole duplication, and how the critical cell cycle kinase Mps1 contributes to regulate this. Though Mps1's role in centriole duplication is not an essential one, yet this kinase, either in the active or even in the inactive form may regulate centrosome biology. This aspect truly fascinates me, as this suggests a complex critical biological process in cells. It would be extremely exciting to know how Mps1 may regulate primary cilia assembly or disassembly as well. Outside of science, I enjoy spending time in nature, especially hiking in the mountains. It helps to relax and clear my mind, improves my focus, and keeps me motivated when I return to my work. If I ever receive paid leave, then I would like to join a mountain training course, which includes rock climbing, basic rescue technic, water and snow skiing. This course would help me to improve my physical fitness and prepare me to explore the higher altitude area and would allow me to assist other travellers for survival in such critical environment.