ID2 Suppresses Multiple Myeloma Cell Proliferation by Repressing the Activity of the Transcription Factor TCF3
Multiple myeloma cells exploit the oncogenic and proliferative potential of TCF3 by downregulating the transcriptional regulator ID2, a process facilitated by the bone marrow microenvironment.
Authors
- Charles B. Epstein (ORCID: https://orcid.org/0000-0001-8358-8345)
- Jessica Encinas (ORCID: https://orcid.org/0000-0003-4479-9822)
- Jessica Fong Ng (ORCID: https://orcid.org/0009-0009-9464-8804)
- Anaïs Schavgoulidze (ORCID: https://orcid.org/0000-0002-5526-4279)
- Shuhui Deng (ORCID: https://orcid.org/0009-0007-6564-8552)
- Lawrence Boise (ORCID: https://orcid.org/0000-0001-9436-8815)
- Eugenio Morelli (ORCID: https://orcid.org/0000-0002-8850-0442)
- Kenneth Carl Anderson (ORCID: https://orcid.org/0000-0002-6418-0886)
- Moritz Binder (ORCID: https://orcid.org/0000-0001-9014-9658)
- Jian Cui (ORCID: https://orcid.org/0000-0002-3885-6782)
- Mehmet Samur (ORCID: https://orcid.org/0000-0002-9978-5682)
- Nikhil C. Munshi (ORCID: https://orcid.org/0000-0002-7344-9795)
- Raphael Elie Szalat (ORCID: https://orcid.org/0000-0002-6198-3405)
- Cassandra White (ORCID: https://orcid.org/0000-0002-6697-4321)
- Mariateresa Fulciniti (ORCID: https://orcid.org/0000-0002-1432-9742)
- Shannon M. Matulis (ORCID: https://orcid.org/0009-0009-4223-2006)
- Adam S. Sperling (ORCID: https://orcid.org/0000-0002-9369-4413)
- Ryan M. Young (ORCID: https://orcid.org/0000-0003-0706-8019)
- Annamaria Gullà (ORCID: https://orcid.org/0000-0003-4569-0095)
- Francesco Ladisa
- Yao Yao (ORCID: https://orcid.org/0000-0002-2905-6425)
- Christopher J. Ott
- Tommaso Perini (ORCID: https://orcid.org/0000-0002-8439-403X)
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Boston Medical Center (US)
- Mayo Clinic (US)
- Emory University (US)
- Xuzhou Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- VA Boston Healthcare System (US)
- Massachusetts General Hospital (US)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Piedmont Cancer Institute (US)
- Dana-Farber Cancer Institute (US)
- IRCCS Ospedale San Raffaele (IT)
- National Cancer Institute (US)
- Ospedale Policlinico San Martino (IT)
- Mayo Clinic in Florida (US)
- Institute of Hematology & Blood Diseases Hospital (CN)
- Center for Cancer Research (US)
- Candiolo Cancer Institute (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Winship Cancer Institute
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1158/2643-3230.bcd-25-0048
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00