Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid, which are reported to function as chelating agents in cosmetic products. The Panel reviewed the available data to determine the safety of these ingredients. The Panel concluded that Tetrasodium Glutamate Diacetate is safe in cosmetics in the practices of use and concentration described in this safety assessment, and that the available data are insufficient to make a determination that Beta-Alanine Diacetic Acid is safe under the intended conditions of use in cosmetic formulations.

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Publication Details

Journal
International Journal of Toxicology
Published
2025-10-17
DOI
https://doi.org/10.1177/10915818251344597
Primary Topic
Contact Dermatitis and Allergies
Type
article
Field-Weighted Citation Impact
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article

Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics

Paul W. Snyder, Monice M. Fiume, D. Belsito, Ronald C. Shank et al.
International Journal of Toxicology
Contact Dermatitis and Allergies
article

Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics

Paul W. Snyder, Monice M. Fiume, D. Belsito, Ronald C. Shank, Lisa A. Peterson, D.C. Liebler, Bart A. Heldreth, Thomas J. Slaga, Wilma Fowler Bergfeld, Curtis D. Klaassen, Christina L. Burnett, David E. Cohen, James G. Marks
article en

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid, which are reported to function as chelating agents in cosmetic products. The Panel reviewed the available data to determine the safety of these ingredients. The Panel concluded that Tetrasodium Glutamate Diacetate is safe in cosmetics in the practices of use and concentration described in this safety assessment, and that the available data are insufficient to make a determination that Beta-Alanine Diacetic Acid is safe under the intended conditions of use in cosmetic formulations.

International Journal of ToxicologyVol. 44(4_suppl)
Openalex Percentile: Top 50%
Contact Dermatitis and Allergies
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Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics — Paul W. Snyder, Monice M. Fiume, et al. · International Journal of Toxicology (2025) | TGRS Research Map | TGRS