Neurotherapeutic effects of Vutiglabridin as a Paraoxonase-2 modulator in preclinical models of Parkinson’s disease
These findings indicate that Vutiglabridin may serve as a promising therapeutic approach for reducing reactive oxygen species (ROS) levels by modulating PON2 activity in Parkinson's diseases.
Authors
- Sun Kyung Park
- Hyeong Min Lee (ORCID: https://orcid.org/0000-0003-3065-6783)
- Leo Sungwong Choi (ORCID: https://orcid.org/0000-0001-8850-0832)
- Suyeol Im (ORCID: https://orcid.org/0000-0003-4466-8224)
- In Young Hwang (ORCID: https://orcid.org/0000-0003-0470-6177)
- Woojin Won (ORCID: https://orcid.org/0000-0001-5262-039X)
- Sora Kang (ORCID: https://orcid.org/0000-0002-1137-2593)
- Jaejin Shin (ORCID: https://orcid.org/0000-0002-1879-6700)
- Changjoon Justin Lee (ORCID: https://orcid.org/0000-0002-3555-0980)
- Youngmi Kim Pak (ORCID: https://orcid.org/0000-0001-7424-3484)
- Dong Hwan Kim
- Sang‐Ku Yoo (ORCID: https://orcid.org/0000-0002-2090-4256)
- Mridula Bhalla (ORCID: https://orcid.org/0000-0001-6045-3683)
- Hyung Soon Park (ORCID: https://orcid.org/0000-0003-0558-2874)
- Hyun Ju Jeon (ORCID: https://orcid.org/0000-0002-6434-8116)
- Sunpil Kim (ORCID: https://orcid.org/0000-0003-1817-3017)
- Kwang Pyo Kim (ORCID: https://orcid.org/0000-0003-0095-3787)
- Jaemin Lee (ORCID: https://orcid.org/0000-0002-0224-7141)
- So Young Kim (ORCID: https://orcid.org/0000-0003-2258-7490)
- Min‐Ho Park (ORCID: https://orcid.org/0000-0003-0891-8230)
- Heeyoung An
- Ji Hwan Kim (ORCID: https://orcid.org/0000-0002-4598-8855)
- Keun Woo Lee (ORCID: https://orcid.org/0000-0002-0627-1800)
- Jae Ho Lee (ORCID: https://orcid.org/0009-0003-8543-5774)
- Jung Hee Park (ORCID: https://orcid.org/0000-0002-4800-628X)
- Byoung Dae Lee
- P.-G. Kim
Institutions
- Kyung Hee Cyber University (KR)
- Gyeongsang National University (KR)
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- Kyung Hee University (KR)
- Institute for Basic Science (KR)
- Kyung Hee University Medical Center (KR)
- Glaceum (South Korea) (KR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s13024-025-00896-z
- Primary Topic
- Paraoxonase enzyme and polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Michael J. Fox Foundation for Parkinson's Research
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea