Maresin 1 Ameliorates Blue Light Overexposure-Induced Meibomian Gland Dysfunction via Inhibition of NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis
Our study indicated that MaR1 alleviated blue light-induced MGD by inhibiting NLRP3/caspase 1/GSDMD-mediated pyroptosis. This finding provides a novel therapeutic perspective for the treatment of environment-related dry eye disease.
Authors
- Mingchang Zhang (ORCID: https://orcid.org/0000-0003-1886-8572)
- Hua-Tao Xie (ORCID: https://orcid.org/0000-0003-4027-691X)
- Weixing Cai (ORCID: https://orcid.org/0000-0001-5506-7008)
- Suna Zhou (ORCID: https://orcid.org/0000-0002-4233-9200)
- Bei Wang (ORCID: https://orcid.org/0000-0001-5587-5451)
- Chao Wang (ORCID: https://orcid.org/0000-0002-7460-7628)
- Yuzhi Li (ORCID: https://orcid.org/0000-0001-9062-8085)
- Meng Wu (ORCID: https://orcid.org/0000-0003-2111-2645)
- Hongbo He (ORCID: https://orcid.org/0000-0002-4456-644X)
- Ni Xiong
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1167/iovs.66.13.29
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wuhan Union Hospital
- Fundamental Research Funds for the Central Universities