Circadian clock proteins BMAL1 and CLOCK regulate HSV-1 entry into nerve cells through NECTIN-1
Together, our findings reveal a novel mechanism by which the circadian clock modulates HSV-1 entry through rhythmic regulation of the NECTIN-1 receptor. BMAL1 and CLOCK emerge as potential therapeutic targets for circadian-based antiviral strategies.
Authors
- Guangyuan Yu (ORCID: https://orcid.org/0000-0003-4738-8105)
- Jiahui Liu (ORCID: https://orcid.org/0009-0003-2526-423X)
- Shuai Wang (ORCID: https://orcid.org/0000-0002-9252-7496)
- Li Feng (ORCID: https://orcid.org/0000-0003-0850-0061)
- Jingyuan Tang (ORCID: https://orcid.org/0000-0002-9720-3060)
- Meifang Pan
Institutions
- Guangzhou University of Chinese Medicine (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- China International Science and Technology Cooperation (CN)
- Guangzhou Center for Disease Control and Prevention (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Eighth People's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12985-025-02936-y
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China