Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer
Our SDH inhibitors halt tumor growth and migration by targeting key substrate binding sites, showing superior efficacy over existing small molecule antagonists. They also modulate SDH protein expression, suggesting a promising dual-targeting strategy for cancer therapy. This study sheds light on SDH function in cancer-related metabolic dysfunction and underscores the potential of SDH modulation as a therapeutic strategy for lung cancer and beyond.
Authors
- Nicholas Skiados (ORCID: https://orcid.org/0000-0001-9661-4127)
- Terrence E. O’Brien (ORCID: https://orcid.org/0000-0002-5621-5065)
- Wen Cai Zhang (ORCID: https://orcid.org/0000-0002-5274-527X)
- Stephanie Contreras
- Manish Gupta (ORCID: https://orcid.org/0000-0002-1949-2231)
- Nikitha Murugavel
- Luís F.O. Silva (ORCID: https://orcid.org/0000-0001-7678-9130)
- Karen Cover
- Nastassja Luna
Institutions
- University of Central Florida (US)
- Healthwise (US)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12935-025-04002-7
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- University of Central Florida