Personalised antiemetic prophylaxis with NEPA for patients at high risk of chemotherapy-induced nausea and vomiting receiving moderately emetogenic chemotherapy: results from the randomised, multinational MyRisk trial
When individual risk factors are considered before MEC, a three-drug regimen including NEPA provides superior CINV prevention across multiple cycles compared with the standard two-drug approach. These findings underscore the value of personalised risk-adapted antiemetic strategies and have practice-changing potential for optimising antiemetic control.
Authors
- E.J. Roeland
- A. Alonzi
- Silvia Olivari Tilola
- Daniel C. Christoph (ORCID: https://orcid.org/0000-0002-3151-6427)
- Alex Molassiotis (ORCID: https://orcid.org/0000-0001-6351-9991)
- M. Majem
- E. Tomlins
- Matti Aapro (ORCID: https://orcid.org/0000-0003-3570-8319)
- M. Karthaus (ORCID: https://orcid.org/0009-0009-8724-7172)
- Martina Zimovjanová (ORCID: https://orcid.org/0000-0001-5261-3501)
- Karin Jordan (ORCID: https://orcid.org/0000-0001-9379-5938)
- Xun‐Xi Lu (ORCID: https://orcid.org/0000-0002-5118-0377)
- K. Syrigos
- Pilar Alfonso (ORCID: https://orcid.org/0000-0003-1201-1690)
- D. Mavroudis
- Lee S. Schwartzberg (ORCID: https://orcid.org/0000-0002-7433-3428)
- E Vazquez (ORCID: https://orcid.org/0000-0002-8456-537X)
- Tomáš Büchler (ORCID: https://orcid.org/0000-0001-6667-994X)
- V. Stimamiglio
- Zhe Zhou (ORCID: https://orcid.org/0000-0003-3253-6355)
- Ying Cheng (ORCID: https://orcid.org/0000-0002-4632-6618)
- George Dranitsaris (ORCID: https://orcid.org/0000-0002-2943-7770)
- E. Bonizzoni
Institutions
- Oregon Health & Science University (US)
- University of Derby (GB)
- Heidelberg University (DE)
- Hospital de Sant Pau (ES)
- University Hospital Heidelberg (DE)
- Renown Health (US)
- Shanghai Chest Hospital (CN)
- Hospital General Universitario Gregorio Marañón (ES)
- Clinique de Genolier (CH)
- Helsinn (Switzerland) (CH)
- Royal Marsden Hospital (GB)
- Derby College (GB)
- Augmentium Pharma Consulting (Canada) (CA)
- University Hospital of Heraklion (GR)
- Complexo Hospitalario Universitario A Coruña (ES)
- Thomayer University Hospital (CZ)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- München Klinik Neuperlach (DE)
- Evangelisches Krankenhaus Königin Elisabeth Herzberge (DE)
- Klinikum Ernst von Bergmann (DE)
- General University Hospital in Prague (CZ)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Annals of Oncology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1016/j.annonc.2025.10.017
- Citations
- 2
- Primary Topic
- Nausea and vomiting management
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Helsinn