Stability Matters: Revealing Causal Roles of G-Quadruplexes (G4s) in Regulation of Chromatin and Transcription
These findings establish thermostability-though measured in vitro-as an intrinsic property that shapes eG4 functionality. Our study not only provides novel insights into the functional relevance of G4 thermostability but also introduces a generalizable framework for high-throughput G4 data interpretation, significantly advancing the functional decoding of eG4s across biological contexts.
Authors
- Tiantong Tao (ORCID: https://orcid.org/0000-0002-7440-4863)
- Hao Huang (ORCID: https://orcid.org/0000-0002-5570-6145)
- Huiling Shu (ORCID: https://orcid.org/0000-0001-8927-1525)
- Jing Tu (ORCID: https://orcid.org/0000-0002-1310-5915)
- Ke Xiao (ORCID: https://orcid.org/0000-0002-0169-4185)
- Xiao Sun (ORCID: https://orcid.org/0000-0003-1048-7775)
- Rongxin Zhang (ORCID: https://orcid.org/0000-0002-1643-1185)
Institutions
- State Key Laboratory of Digital Medical Engineering (CN)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Southeast University (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3390/genes16101231
- Citations
- 1
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.81