Enhanced ADCC Activity of a C-Terminal Lysine Variant of an IgG1 Antibody Driven by N-Linked MAN5 Glycan Using a Reporter Gene Assay
These findings challenge previous assumptions about the role of C-terminal lysine in ADCC, suggesting a shift in understanding the functional significance of charge variants and emphasizing the critical influence of glycan composition in therapeutic antibody efficacy.
Authors
- Alice M. Matathia
- Jingming Zhang (ORCID: https://orcid.org/0000-0002-0961-934X)
- Jun Qian (ORCID: https://orcid.org/0000-0002-2649-8121)
- Timothy Blanc
- Diane Vy
- Babita Saxena Parekh
- Chao Li (ORCID: https://orcid.org/0000-0001-5723-1414)
- Ming-Ching Hsieh
- Kristiina Dorofejeva
Institutions
- Eli Lilly (United States) (US)
Publication Details
- Journal
- Antibodies
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3390/antib14040089
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00