Discovering anticancer drug target combinations via network-informed signaling-based approach
Our network-based approach discovers optimal protein co-target combinations to counter resistance, selecting co-targets from alternative pathways and their connectors.
Authors
- Bengi Ruken Yavuz (ORCID: https://orcid.org/0000-0002-3472-8767)
- Ruth Nussinov (ORCID: https://orcid.org/0000-0002-8115-6415)
- Hyunbum Jang (ORCID: https://orcid.org/0000-0001-9402-4051)
Institutions
- Tel Aviv University (IL)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1038/s43856-025-01150-9
- Citations
- 3
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Cancer Institute