Bone Metastatic Progression of Prostate Cancer Is Regulated by TRIM28–LDHA-Mediated Metabolism
TRIM28 upregulates LDHA and glycolysis, propelling prostate tumors in the bone; pharmacologic LDH blockade mitigates disease.
Authors
- Ryan Goettl
- Miyeong Kim
- Ka-wing Fong (ORCID: https://orcid.org/0000-0001-6995-0264)
- Cong Han (ORCID: https://orcid.org/0000-0001-8072-1884)
- Jinpeng Liu (ORCID: https://orcid.org/0000-0003-4100-0237)
Institutions
- University of Kentucky (US)
- Markey Cancer Center (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1158/1541-7786.mcr-25-0676
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52