Prevalence and Associated Factors of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease: An Updated Global Systematic Review and Meta-Analysis of over 1.5 Million Individuals
NAFLD is a common comorbidity among patients with IBD, affecting over one in four individuals, with higher prevalence observed in adults, males, and certain geographic regions. Variation by diagnostic modality and disease location was also noted; however, these subgroup findings are based on limited data and should be interpreted with caution. Overall, the results highlight the importance of incorporating liver health screening into routine IBD management, particularly for high-risk populations, and underscore the need for future prospective studies to refine risk stratification and management strategies.
Authors
- Bahar Darouei (ORCID: https://orcid.org/0000-0002-5269-0061)
- Madhusudhan Ponnala
- Sandeep Samethadka Nayak (ORCID: https://orcid.org/0009-0000-1601-1466)
- Nitya Rao (ORCID: https://orcid.org/0000-0002-6318-0147)
- Seyyed Mohammad Reza Hashemi (ORCID: https://orcid.org/0000-0002-3895-2176)
- Mohammad‐Hossein Keivanlou (ORCID: https://orcid.org/0000-0002-5305-1288)
- Michael T. Ulrich (ORCID: https://orcid.org/0000-0002-8523-5807)
- Shahriar Ghodous (ORCID: https://orcid.org/0009-0003-9902-2313)
- Ehsan Amini‐Salehi (ORCID: https://orcid.org/0000-0003-4985-2899)
- Kwame Agyeman
- Mohammad‐Javad Khosousi (ORCID: https://orcid.org/0000-0002-2896-8094)
- Reza Amani‐Beni (ORCID: https://orcid.org/0000-0002-8383-6676)
- Amir Nasrollahizadeh (ORCID: https://orcid.org/0000-0001-6328-8468)
- Negin Letafatkar (ORCID: https://orcid.org/0009-0000-7980-8720)
- Mohammad Amin Karimi (ORCID: https://orcid.org/0000-0002-0638-1743)
- Yussif Issaka (ORCID: https://orcid.org/0009-0007-2538-6172)
- Parsa Saberian (ORCID: https://orcid.org/0000-0002-8889-8630)
- Farahnaz Joukar
- Arman Habibi (ORCID: https://orcid.org/0009-0003-1438-704X)
- Pubali Biswas
- Simran Joshi
- Mehrdad Khorasani
- Anoop Gurram
- Yasmin Sahli
- Kiran Sandilya Balivada
- Anderson Ogazi
Institutions
- Isfahan University of Medical Sciences (IR)
- Holy Spirit Hospital (IN)
- Cleveland Clinic (US)
- Guilan University of Medical Sciences (IR)
- Loma Linda University (US)
- Metropolitan Hospital Center (US)
- Riverside University Health System - Medical Center (US)
- Bridgeport Hospital (US)
- Yale University (US)
- University of Massachusetts Boston (US)
- Loma Linda University Health Care (US)
- Arnot Ogden Medical Center (US)
- Yale New Haven Health System (US)
- Hormozgan University of Medical Sciences (IR)
- Kidney Associates (US)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1093/ibd/izaf226
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71