Dual β-lactam synergy in <i>Enterococcus faecalis</i> and its relationship with penicillin-ceftriaxone infective endocarditis treatment outcomes
Ceftriaxone susceptibility, either MIC <512 mg/L by BMD or disc zone diameter >6 mm, is the best predictor of ampicillin-ceftriaxone and particularly benzylpenicillin-ceftriaxone synergy in E. faecalis. There was no clear relationship between the absence of benzylpenicillin-ceftriaxone synergy and outcome in this highly comorbid cohort.
Authors
- Shakeel Mowlaboccus (ORCID: https://orcid.org/0000-0001-9408-6068)
- Indy Sandaradura (ORCID: https://orcid.org/0000-0002-9457-8262)
- Sophia Rizzo
- Aric L. Gregson (ORCID: https://orcid.org/0000-0001-6806-0868)
- Geoffrey W. Coombs (ORCID: https://orcid.org/0000-0003-1635-6506)
- Genevieve McKew (ORCID: https://orcid.org/0000-0002-5238-9260)
- Elena Martínez
- Sruthi Mamoottil Sudeep
- Jignasa Purani
Institutions
- The University of Sydney (AU)
- Concord Hospital (US)
- Murdoch University (AU)
- Concord Repatriation General Hospital (AU)
- Fiona Stanley Hospital (AU)
- Westmead Hospital (AU)
- Westmead Institute for Medical Research (AU)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1093/jac/dkaf377
- Primary Topic
- Infective Endocarditis Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Murdoch University