Diagnosis and Treatment Response Monitoring of Liver Cancer Using Glypican-3–Targeted Single-Domain Antibody PET
We successfully designed, engineered, and tested a GPC3-targeted 18F-labeled nanobody immunoPET agent, Al[18F]F-ssHN3, demonstrating that it can be used for same-day diagnostic imaging in murine models of liver cancer. Importantly, this agent could address the limitations of current imaging methods by detecting residual disease after thermal ablation and other locoregional therapies.
Authors
- Stanley Fayn (ORCID: https://orcid.org/0000-0003-3313-2934)
- Ross W. Cheloha (ORCID: https://orcid.org/0000-0001-9871-8333)
- Jesse Buffington (ORCID: https://orcid.org/0009-0009-9751-7199)
- Bradford J. Wood (ORCID: https://orcid.org/0000-0002-4297-0051)
- Joon‐Yong Chung (ORCID: https://orcid.org/0000-0001-5041-5982)
- Mitchell Ho (ORCID: https://orcid.org/0000-0002-9152-5405)
- Orit Jacobson (ORCID: https://orcid.org/0009-0004-7088-470X)
- Falguni Basuli (ORCID: https://orcid.org/0000-0001-7454-9002)
- Hima Makala (ORCID: https://orcid.org/0000-0003-4534-7975)
- Jianfeng Shi (ORCID: https://orcid.org/0009-0000-4866-9449)
- Rolf E. Swenson (ORCID: https://orcid.org/0000-0001-7804-7202)
- Colleen P. Olkowski (ORCID: https://orcid.org/0000-0002-2370-0582)
- Freddy E. Escorcia (ORCID: https://orcid.org/0000-0002-0727-3242)
- Peter L. Choyke (ORCID: https://orcid.org/0000-0003-1086-8826)
- Robert Morhard (ORCID: https://orcid.org/0000-0001-8875-471X)
- Dan Li (ORCID: https://orcid.org/0000-0002-9783-5340)
- Woong Hee Lee (ORCID: https://orcid.org/0000-0003-0279-5268)
- Divya Nambiar (ORCID: https://orcid.org/0009-0008-5460-8114)
Institutions
- National Institutes of Health (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- CRUK/MRC Oxford Institute for Radiation Oncology (GB)
- National Heart, Lung, and Blood Institute (US)
- National Cancer Institute (UA)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2587
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00