Dendrobine ameliorates mitophagy-mediated endothelial senescence in diabetic kidney disease through activating the SIRT1/FOXO3a pathway
These findings demonstrate that Den ameliorates endothelial senescence in DKD by enhancing mitophagy through activating the SIRT1/FOXO3a pathway, highlighting a promising therapeutic strategy for DKD patient.
Authors
- Wei Wang (ORCID: https://orcid.org/0000-0003-2302-6273)
- Yan Yang (ORCID: https://orcid.org/0000-0003-1421-8003)
- Rong Sun (ORCID: https://orcid.org/0000-0002-0950-1480)
- Yongsheng He (ORCID: https://orcid.org/0000-0001-6352-6286)
- Yu-Sheng Shi (ORCID: https://orcid.org/0000-0002-8474-4335)
- Y Z Gong (ORCID: https://orcid.org/0009-0008-0060-2059)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-4119-7359)
- Xuan Qi (ORCID: https://orcid.org/0000-0002-1263-804X)
- Hongkai Yang (ORCID: https://orcid.org/0009-0005-2303-0725)
Institutions
- Dalian Medical University (CN)
- Anhui Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Anshan Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1186/s13020-025-01234-7
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22