Mitochondrial dysfunction-related metabolite methylmalonic acid is associated with decreased cognitive performance
The findings indicate that elevated MMA levels are linked to cognitive decline in older adults, potentially through mitochondrial dysfunction. These results underscore the clinical importance of MMA in the context of chronic cognitive impairment.
Authors
- Shaohong Fang (ORCID: https://orcid.org/0000-0001-8635-857X)
- Weihua Guo (ORCID: https://orcid.org/0000-0002-5839-7114)
- Ruishan Li (ORCID: https://orcid.org/0000-0002-1452-4505)
- Fan Tang (ORCID: https://orcid.org/0000-0003-3074-2198)
- Yige Liu (ORCID: https://orcid.org/0000-0003-0628-1344)
- Peng Wu (ORCID: https://orcid.org/0000-0002-3793-0653)
- Jiaxin Wang (ORCID: https://orcid.org/0000-0002-7038-923X)
- Xinran Wang (ORCID: https://orcid.org/0000-0002-2911-9051)
- Yiying Zhang (ORCID: https://orcid.org/0000-0001-9965-2276)
Institutions
- Jiamusi University (CN)
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1371/journal.pone.0332987
- Citations
- 1
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.32