Fractionation increasingly reduces FLASH sparing for acute murine skin damage
Fractionation increasingly reduced the acute skin-sparing effect seen in single-fraction FLASH studies. However, a tissue-sparing effect of 18 % was still present at four fractions, while eight fractions provided a nonsignificant 5 % FLASH skin-sparing. Clinical implementation of FLASH may work best in highly hypofractionated settings.
Authors
- Jacob Johansen (ORCID: https://orcid.org/0000-0001-8475-0447)
- Line Kristensen (ORCID: https://orcid.org/0000-0003-0924-475X)
- Lars Hjorth Præstegaard
- Brita Singers Sørensen (ORCID: https://orcid.org/0000-0002-3955-4735)
- Axel Kornerup Hansen (ORCID: https://orcid.org/0000-0003-1575-2507)
- P.R. Poulsen (ORCID: https://orcid.org/0000-0001-9940-7609)
- Lone Hoffmann (ORCID: https://orcid.org/0000-0002-3575-0421)
- Sky Rohrer
Institutions
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1016/j.radonc.2025.111209
- Citations
- 2
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Novo Nordisk
- Novo Nordisk Fonden
- Siemens Healthineers