International Session 3　　Equilibrium Research 1

PurposeTo explore the link between working behaviors and sensorineural hearing loss(SNHL) .MethodsA cross-sectional (n90286)and a prospective analysis(n8 341)were conducted to assess the association between working behaviors(including shift work, night shift work and physical work)and the occurrence, laterality, and severity of SNHL.Multivariable logistic regression and Cox regression models were applied.Subgroup analyses were conducted by age, sex, and chronotype.A polygenic risk score(PRS)was calculated to assess genetic susceptibility's impact.Results and DiscussionCross-sectional and prospective analysis revealed that shift work, night shift work, and physical work correlated with a higher risk of SNHL.Increased frequencies of these behaviors were linked to more severe SNHL and bilateral involvement(all p0 05) .The link between night shift work and SNHL was stronger in morning chronotype individuals(P-interaction0 003) .Despite the genetic risk, there remained a positive association between working behaviors with SNHL.ConclusionsShift work, night shift work, and physical work increase the risk of SNHL occurrence, laterality, and severity.