Diagnosis and Management of AML in Pediatric Patients: Consensus Recommendations from an International Expert Panel
The European LeukemiaNet has periodically issued guidelines for the diagnosis and management of acute myeloid leukemia (AML) in adults. These consensus recommendations, most recently updated in 2022, incorporate recent advances in genomic testing, disease detection methods, target identification, and response assessment. Whilst similarities exist between AML in children and adults, pediatric AML is frequently characterized by unique cytogenetic and molecular features, which require distinct genetic and immunophenotypic diagnostics, therapeutic approaches, response assessment criteria, and supportive care strategies. To address these specific needs, an international panel of pediatric hematologist-oncologists, biologists, geneticists, and laboratory medicine scientists convened to develop recommendations for the diagnosis and management of AML in children, adolescents, and young adults (hereafter termed pediatric AML) that are discussed in this special report.
Authors
- Martina Pigazzi (ORCID: https://orcid.org/0000-0002-4793-5263)
- Thomas Lehrnbecher (ORCID: https://orcid.org/0000-0002-6022-3439)
- E. Anders Kolb (ORCID: https://orcid.org/0000-0003-2854-9014)
- Franco Locatelli (ORCID: https://orcid.org/0000-0002-7976-3654)
- Anne Tierens (ORCID: https://orcid.org/0000-0002-5350-8313)
- Linda Fogelstrand (ORCID: https://orcid.org/0000-0003-3698-8519)
- Bianca F. Goemans (ORCID: https://orcid.org/0000-0003-4030-3228)
- Daisuke Tomizawa (ORCID: https://orcid.org/0000-0003-1520-7007)
- Jan‐Henning Klusmann (ORCID: https://orcid.org/0000-0002-1070-0727)
- Matthew A. Kutny (ORCID: https://orcid.org/0000-0002-6659-7036)
- Betsy Hirsch (ORCID: https://orcid.org/0000-0003-0162-6905)
- Richard Aplenc (ORCID: https://orcid.org/0000-0001-7482-5644)
- Todd M. Cooper (ORCID: https://orcid.org/0000-0002-1203-2371)
- Arnaud Petit (ORCID: https://orcid.org/0000-0001-8363-1622)
- Gertjan J.L. Kaspers (ORCID: https://orcid.org/0000-0001-7716-8475)
- Barbara Buldini (ORCID: https://orcid.org/0000-0001-7285-2390)
- Soheil Meshinchi (ORCID: https://orcid.org/0000-0002-6276-4423)
- Michael Dworzak (ORCID: https://orcid.org/0000-0002-8175-1097)
- Sarah K. Tasian (ORCID: https://orcid.org/0000-0003-1327-1662)
- Barbara De Moerloose (ORCID: https://orcid.org/0000-0002-2449-539X)
- Henrik Hasle (ORCID: https://orcid.org/0000-0003-3976-9231)
- Dirk Reinhardt (ORCID: https://orcid.org/0000-0002-7027-4483)
- Lisa Eidenschink Brodersen (ORCID: https://orcid.org/0000-0002-6747-4695)
- C. Michel Zwaan
- Brenda Gibson
Institutions
- Goethe University Frankfurt (DE)
- Seattle Children's Hospital (US)
- University Health Network (CA)
- Alfred I. duPont Hospital for Children (US)
- Children's Hospital of Philadelphia (US)
- University of Padua (IT)
- Royal Hospital for Children (GB)
- University of Minnesota System (US)
- Sahlgrenska University Hospital (SE)
- Ghent University Hospital (BE)
- Aarhus University Hospital (DK)
- University of Alabama at Birmingham (US)
- Sorbonne Université (FR)
- Hôpital Armand-Trousseau (FR)
- Fred Hutch Cancer Center (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Bambino Gesù Children's Hospital (IT)
- St Anna Children's Hospital (AT)
- Princess Máxima Center (NL)
- National Center For Child Health and Development (JP)
- University of Pennsylvania (US)
Publication Details
- Journal
- Blood
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1182/blood.2024027904
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- U.S. Department of Defense
- Amgen
- Pfizer
- AstraZeneca
- Sanofi
- Pennsylvania Department of Health
- Children's Hospital of Philadelphia
- Seattle Children's Research Institute
- Jazz Pharmaceuticals
- bluebird bio
- BeiGene
- Incyte
- Syndax Pharmaceuticals
- Swedish Orphan Biovitrum
- National Institutes of Health
- National Cancer Institute
- Daiichi Sankyo Europe