Changes in ferroptosis-related molecular expression in macrophages of community-acquired pneumonia patients and their associated with the disease progression
Ferroptosis is intricately involved in CAP pathogenesis, with altered expression of key molecules contributing to disease progression. Our findings highlight the potential of targeting ferroptosis-related molecules (e.g., TP53, GPX4, and PTGS2) as a novel therapeutic strategy to mitigate inflammation and tissue damage in CAP. Future studies should validate these findings in larger cohorts.
Authors
- Junlin Chi
- Yanguang Cong (ORCID: https://orcid.org/0000-0001-6630-6078)
- Le-Yao Xiao
- Jiang Pi (ORCID: https://orcid.org/0000-0003-4418-1248)
- Jiajun Wang (ORCID: https://orcid.org/0000-0003-1824-6837)
- Jun-Fa Xu (ORCID: https://orcid.org/0000-0002-5299-8883)
- Huan-Shao Huang
- Lan Chen (ORCID: https://orcid.org/0009-0006-3087-4528)
- Yiming Shao (ORCID: https://orcid.org/0000-0002-3537-9546)
- Shi-Ying Lai (ORCID: https://orcid.org/0009-0009-2124-8498)
Institutions
- Guangdong Medical College (CN)
- Dongguan University of Technology (CN)
- Songshan Lake Materials Laboratory (CN)
- Dongguan People’s Hospital (CN)
Publication Details
- Journal
- Inflammation Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1007/s00011-025-02116-2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province