Association of BMI, BMR, BSA, and body weight with psoriasis severity and treatment response: evidence from a real-world cohort
Elevated BMI, BSA, body weight, and BMR are associated with more severe psoriasis and diminished treatment efficacy, especially those treated with biologics. These findings underscore the need for personalized dosing strategies in biologic therapy, especially for fixed-dose agents like ustekinumab.
Authors
- Chen Peng (ORCID: https://orcid.org/0000-0003-1052-4484)
- Rui Ma (ORCID: https://orcid.org/0000-0002-4841-0047)
- Yangfeng Ding
- Yuling Shi (ORCID: https://orcid.org/0000-0002-1273-7881)
- Yue Yin (ORCID: https://orcid.org/0000-0001-6497-5382)
- Qian Yu (ORCID: https://orcid.org/0000-0001-9774-9226)
- Xin Wang (ORCID: https://orcid.org/0009-0007-0171-8355)
- Y. C. Xu (ORCID: https://orcid.org/0009-0007-7340-7871)
- Yizhen Zhang (ORCID: https://orcid.org/0000-0002-7783-4420)
- Yuanyi Zhen
- Suwei Tang
Institutions
- Tongji University (CN)
- Shanghai Skin Disease Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12967-025-07130-w
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Education Commission
- National Key Research and Development Program of China