Oxidative stress triggers Itch-mediated TXNIP degradation and NF-κB activation promoting chronic obstructive pulmonary disease
Accordingly, CS-induced oxidative stress promotes Itch-mediated TXNIP degradation, leading to NF-κB-driven inflammation in macrophages and potentially contributing to COPD pathogenesis.
Authors
- Fu-Chia Shih
- Pei‐Yun Lin (ORCID: https://orcid.org/0000-0002-9944-4730)
- Hsiao‐Chi Chuang (ORCID: https://orcid.org/0000-0003-4651-5192)
- Rahmat Dani Satria (ORCID: https://orcid.org/0000-0002-7910-4325)
- Shu‐Chuan Ho (ORCID: https://orcid.org/0000-0002-1616-8647)
- Chiou‐Feng Lin (ORCID: https://orcid.org/0000-0003-4396-6086)
- Kang‐Yun Lee (ORCID: https://orcid.org/0000-0003-4705-5802)
- Bing-Hua Su
- Tsung-Ting Tsai (ORCID: https://orcid.org/0000-0002-7647-788X)
- Chia‐Ling Chen (ORCID: https://orcid.org/0000-0003-2161-4362)
- Po-Chun Tseng
- Ying-Jung Wu
Institutions
- Universitas Gadjah Mada (ID)
- Wan Fang Hospital (TW)
- Rumah Sakit Umum Pusat Dr. Sardjito (ID)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12931-025-03369-5
- Citations
- 5
- Primary Topic
- Redox biology and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Taipei Medical University
- National Science and Technology Council