Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation

Pancreatic oncogenic KRAS drives premetastatic niche formation in the lungs, but not liver, through fibroblast STAT3 activation to promote metastasis, indicating a lung-specific vulnerability for treating pancreatic cancer metastasis. See related commentary by Mucciolo and Biffi, p. 7.

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Publication Details

Journal
Cancer Research
Published
2025-10-17
DOI
https://doi.org/10.1158/0008-5472.can-25-3472
Citations
2
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
Field-Weighted Citation Impact
2.09
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Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation

Emily L. Lasse Opsahl, Ahmed M. Elhossiny, Faith R. Avritt, Hannah R. Watkoske et al.
2 citations
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Pancreatic and Hepatic Oncology Research
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Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation

Emily L. Lasse Opsahl, Ahmed M. Elhossiny, Faith R. Avritt, Hannah R. Watkoske, Allison C. Bischoff, Eileen S. Carpenter, Kyoung Eun Lee, Jude Ogechukwu Okoye, Carlos E. Espinoza, Katelyn L. Donahue, Megan T. Hoffman, Yaqing Zhang, Julianne M. Szczepanski, Padma Kadiyala, Marina Pasca di Magliano, Jiaqi Shi, Timothy L. Frankel, Alberto C. Olivei, Mary Poggi, Nandini Arya
article en
2 citations

Abstract

Pancreatic oncogenic KRAS drives premetastatic niche formation in the lungs, but not liver, through fibroblast STAT3 activation to promote metastasis, indicating a lung-specific vulnerability for treating pancreatic cancer metastasis. See related commentary by Mucciolo and Biffi, p. 7.

Cancer ResearchVol. 86(1)
Harvard University (US), Nnamdi Azikiwe University (NG), University of Michigan (US), Michigan United (US), Michigan Medicine (US), Dana-Farber Cancer Institute (US), Michigan Center for Translational Pathology (US), Ann Arbor Center for Independent Living (US)
Openalex Percentile: Top 10%
Pancreatic and Hepatic Oncology Research
2.09
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