Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation
Pancreatic oncogenic KRAS drives premetastatic niche formation in the lungs, but not liver, through fibroblast STAT3 activation to promote metastasis, indicating a lung-specific vulnerability for treating pancreatic cancer metastasis. See related commentary by Mucciolo and Biffi, p. 7.
Authors
- Emily L. Lasse Opsahl (ORCID: https://orcid.org/0000-0001-6371-9459)
- Ahmed M. Elhossiny (ORCID: https://orcid.org/0000-0003-0884-8754)
- Faith R. Avritt (ORCID: https://orcid.org/0009-0003-4570-0350)
- Hannah R. Watkoske (ORCID: https://orcid.org/0000-0003-2518-6457)
- Allison C. Bischoff (ORCID: https://orcid.org/0000-0001-5119-5272)
- Eileen S. Carpenter (ORCID: https://orcid.org/0000-0001-6775-6943)
- Kyoung Eun Lee (ORCID: https://orcid.org/0000-0002-3955-7389)
- Jude Ogechukwu Okoye (ORCID: https://orcid.org/0000-0002-7194-5592)
- Carlos E. Espinoza (ORCID: https://orcid.org/0009-0000-0460-1514)
- Katelyn L. Donahue (ORCID: https://orcid.org/0000-0001-9535-9275)
- Megan T. Hoffman (ORCID: https://orcid.org/0000-0003-0907-9977)
- Yaqing Zhang (ORCID: https://orcid.org/0000-0002-9185-4364)
- Julianne M. Szczepanski (ORCID: https://orcid.org/0000-0002-5687-9857)
- Padma Kadiyala (ORCID: https://orcid.org/0000-0002-3273-9905)
- Marina Pasca di Magliano (ORCID: https://orcid.org/0000-0001-9632-9035)
- Jiaqi Shi (ORCID: https://orcid.org/0000-0003-4893-1587)
- Timothy L. Frankel (ORCID: https://orcid.org/0000-0001-5987-0404)
- Alberto C. Olivei
- Mary Poggi
- Nandini Arya (ORCID: https://orcid.org/0009-0002-2289-4423)
Institutions
- Harvard University (US)
- Nnamdi Azikiwe University (NG)
- University of Michigan (US)
- Michigan United (US)
- Michigan Medicine (US)
- Dana-Farber Cancer Institute (US)
- Michigan Center for Translational Pathology (US)
- Ann Arbor Center for Independent Living (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1158/0008-5472.can-25-3472
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09