Impaired Bicarbonate Transport via SLC26A3 and CFTR Downregulation Promotes Mucous Cap Formation in Sessile Serrated Lesions
SSLs showed a mixed acidic mucin phenotype and downregulated epithelial bicarbonate transporters. This may impair mucin expansion and hydration, leading to the formation of adhesive mucous caps, showing the potential link between defective bicarbonate transport and mucin physiology in SSLs.
Authors
- Ayako Seki
- Hirotaka Tanabe (ORCID: https://orcid.org/0000-0002-1948-7408)
- Miharu Suzuki
- Takeshi Uehara (ORCID: https://orcid.org/0000-0002-7694-9015)
- Hiroyoshi Ota
- Etsuo Hara
- Yukiko Kusama
Institutions
- Shinshu University (JP)
- Nagano Municipal Hospital (JP)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1007/s10620-025-09470-5
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science