Synthesis and anti-influenza activity of a series of triterpene furoyloxy-acylates
A series of lupane, oleanane and ursane furoyloxy-triterpenoids were synthesised <i>via</i> acylation with 2-furoyl chloride and subsequently tested for anti-influenza activity against the pandemic influenza virus A/Puerto Rico/8/1934 (H1N1). Among them, 3<i>β</i>-furoyloxy-oleanolic and 3<i>β</i>-furoyloxy-ursolic acids were the most potent with IC<sub>50</sub> values 17 and 1 <i>µ</i>M with selectivity indexes of 32 and 26, respectively. The molecular structure of compound <b>11</b> was determined by X-ray diffraction analysis.
Authors
- Dmitriy Polovyanenko (ORCID: https://orcid.org/0009-0000-3835-825X)
- И. Е. Смирнова (ORCID: https://orcid.org/0000-0001-7176-505X)
- Yu. V. Gatilov (ORCID: https://orcid.org/0000-0002-4128-7293)
- О. Б. Казакова (ORCID: https://orcid.org/0000-0002-5606-1588)
- Alexandrina S. Volobueva (ORCID: https://orcid.org/0000-0003-0839-852X)
- Владимир В. Зарубаев (ORCID: https://orcid.org/0000-0002-6837-5242)
- Maria Niukalova
Institutions
- Novosibirsk Institute of Organic Chemistry (RU)
- Saint Petersburg Pasteur Institute (RU)
- Ufa Institute of Chemistry (RU)
- Institute of Virology of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1080/14786419.2025.2569807
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00