IFN-α levels correlate with muscle disease activity only in juvenile dermatomyositis patients with anti-MDA5+ autoantibodies
The exclusive association of IFN-α levels with muscle clinical score in anti-MDA5-positive patients suggests a subgroup-specific pathophysiological mechanism. These findings underscore potentially distinct roles for IFN-I subtypes (IFN-α and IFN-β) as circulating biomarkers of muscle disease activity in JDM according to MSA expression.
Authors
- Naïm Ouldali (ORCID: https://orcid.org/0000-0003-4996-9640)
- Isabelle Melki (ORCID: https://orcid.org/0000-0002-8057-333X)
- Marc H.A. Jansen (ORCID: https://orcid.org/0000-0001-6969-8759)
- Étienne Villain (ORCID: https://orcid.org/0000-0001-9907-9094)
- Cécile Dumaine (ORCID: https://orcid.org/0000-0003-2041-0333)
- Femke van Wijk (ORCID: https://orcid.org/0000-0001-8343-1356)
- Darragh Duffy (ORCID: https://orcid.org/0000-0002-8875-2308)
- Laurye-Anne Eveillard (ORCID: https://orcid.org/0000-0003-1896-4097)
- Brigitte Bader‐Meunier (ORCID: https://orcid.org/0000-0001-8476-8196)
- Juliette Ramos
- Annet van Royen‐Kerkhof (ORCID: https://orcid.org/0009-0009-6874-4421)
- Caroline Vinit
- Marie‐Louise Frémond (ORCID: https://orcid.org/0000-0002-2798-9141)
- Mathieu Paul Rodero (ORCID: https://orcid.org/0000-0002-1300-0187)
- Christine Bodemer (ORCID: https://orcid.org/0000-0001-8772-0905)
- Saskia R Veldkamp (ORCID: https://orcid.org/0000-0002-1626-353X)
- Vincent Bondet (ORCID: https://orcid.org/0000-0002-6534-0984)
- A. Welfringer‐Morin (ORCID: https://orcid.org/0000-0001-7479-3689)
- Benjamin Fournier (ORCID: https://orcid.org/0000-0003-4383-7524)
- Pierre Quartier (ORCID: https://orcid.org/0000-0002-1769-549X)
- T. Moreau (ORCID: https://orcid.org/0009-0000-2965-0400)
- Cyril Gitiaux (ORCID: https://orcid.org/0000-0002-2190-6843)
- G. Dingulu
- J. Merlijn van den Berg (ORCID: https://orcid.org/0000-0003-3026-2784)
- Petra C. E. Hissink Muller (ORCID: https://orcid.org/0000-0003-1610-8721)
- Ngoc-Bao Duong
- Jean‐Luc Charuel
- Wineke Armbrust
- Arnaud Isapof (ORCID: https://orcid.org/0009-0003-7349-9922)
- Samuel Bonhomme
- Diego Bletry
- Marie-Alexandra Alyanakan
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pasteur (FR)
- Utrecht University (NL)
- Université Paris Cité (FR)
- University Medical Center Utrecht (NL)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Hôpital Armand-Trousseau (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Référence des Maladies Autoinflammatoires et des Amyloses (FR)
- Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Robert-Debré (FR)
- Wilhelmina Children's Hospital (NL)
- Institut des Maladies Génétiques Imagine (FR)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1093/rheumatology/keaf549
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00