Viscodilation of Schlemm canal and trabeculotomy for reducing intraocular pressure and medication use in pseudophakic eyes

Plain Language Summary The combination of canaloplasty and trabeculotomy (OMNI Surgical System, Sight Sciences) has been shown to be safe and effective in combination with cataract surgery and as a standalone procedure in pseudophakic eyes, however prospective standalone data including a medication washout at baseline and endpoints as reported herein has not been previously published This was a small, multicenter, single arm study of 2-year effectiveness of OMNI and employing a medication washout at baseline, 12, and 24 months. Eighteen eligible subjects were analyzed. Intraocular pressure (IOP) was reduced from 26.1 mmHg (3.9) at baseline to 16.5 (3.9) and 16.0 (3.2) at 12 and 24 months while medications were reduced from 1.8 (0.9) to 0.9 (1.2) and 0.5 (0.8), respectively. The IOP and medication reductions were statistically significant (all p<.001). Adverse events were generally mild and self-resolving; only one (dry eye) deemed possibly related to the procedure. Plain Language SummaryThis study evaluated the effectiveness of the OMNI Surgical System, which combines canaloplasty and trabeculotomy, as a standalone procedure in pseudophakic eyes over two years. Eighteen subjects underwent a medication washout at baseline, 12, and 24 months. Results showed a significant reduction in intraocular pressure (IOP) from 26.1 mmHg to 16.5 mmHg at 12 months and 16.0 mmHg at 24 months. Medication use also decreased from 1.8 to 0.9 and 0.5 over the same periods. The reductions in IOP and medication were statistically significant, with mild and self-resolving adverse events, except for one case of dry eye. Text is machine generated and may contain inaccuracies. FAQ