Nephrotoxicity of conventional chemotherapeutics: part II—non-platinum agents and miscellaneous nephrotoxic drugs
While modern anticancer therapies have significantly improved survival in patients with cancer, their success is often hindered by unintended side effects and toxicities, particularly to the kidneys. Many conventional chemotherapeutic agents, despite their efficacy, exert nephrotoxic effects that can result in short- and long-term adverse kidney outcomes. This review critically examines the renal implications of non-platinum alkylating agents and other less commonly grouped cytotoxic drugs based on available literature. Nephrotoxicity remains a frequent and often dose-limiting challenge in patients with cancer, even with preventive measures. As such, there is a growing need to identify predictive biomarkers and develop targeted kidney-protective strategies. An understanding of these agents' kidney toxicity profiles is critical to maximize the oncologic benefit while preserving kidney function in this vulnerable population.
Authors
- Adam Kelly
- Omar Mamlouk (ORCID: https://orcid.org/0000-0002-1242-2740)
- Kenar D. Jhaveri (ORCID: https://orcid.org/0000-0003-1578-0524)
- Kartik Kalra
- Tanazul T. Pariswala
- Sylvia S Eskander
- Sourabh Sharma (ORCID: https://orcid.org/0000-0002-9729-5129)
- Mark A. Perazella (ORCID: https://orcid.org/0000-0002-6994-2659)
- Shruti Gupta (ORCID: https://orcid.org/0000-0002-5747-2151)
- Marco A. Bonilla (ORCID: https://orcid.org/0000-0001-9087-9730)
- Mohamed Ibrahim
- Prakash Gudsoorkar (ORCID: https://orcid.org/0000-0001-9044-6054)
- Paul E. Hanna (ORCID: https://orcid.org/0000-0003-4976-9104)
- Mohamed Hassanein (ORCID: https://orcid.org/0000-0002-8247-5936)
- Anna-Eve Turcotte
- Munjal Patel (ORCID: https://orcid.org/0000-0001-6892-0899)
- Raad B. Chowdhury (ORCID: https://orcid.org/0000-0002-9347-6299)
- Carl Dernell
- Huong Truong
- Rimda Wanchoo
- Ishaan Zaveri
Institutions
- Northeastern University (US)
- Geisinger Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Vardhman Mahavir Medical College & Safdarjung Hospital (IN)
- Medical College of Wisconsin (US)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Yale University (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Universal Scientific Education and Research Network (IR)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Dana-Farber Cancer Institute (US)
- Loxo Oncology at Lilly (United States) (US)
- Methodist Dallas Medical Center (US)
- Dana-Farber Brigham Cancer Center (US)
- Children's Specialized Hospital (US)
- Cooper Union (US)
- The University of Texas Health Science Center at Houston (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1093/ndt/gfaf220
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00