Proenkephalin predicts kidney function and major adverse kidney events in CKD
PENK levels are strongly, independently, and inversely associated with renal function in cross-sectional analysis. Furthermore, baseline circulating PENK levels are predictive of a 4P-MARE in patients and added independent, prognostic value for identification of patients at risk for adverse renal outcomes.
Authors
- Ingolf Bast
- Robin Schürfeld (ORCID: https://orcid.org/0000-0002-7488-916X)
- Ralph Wendt (ORCID: https://orcid.org/0000-0003-1600-6581)
- Michael Stümvoll (ORCID: https://orcid.org/0000-0001-6225-8240)
- Thomas Ebert (ORCID: https://orcid.org/0000-0003-1683-9276)
- Ekaterine Baratashvili
- Marleen Würfel (ORCID: https://orcid.org/0009-0004-2071-8463)
- Matthias Blüher (ORCID: https://orcid.org/0000-0003-0208-2065)
- Martin Haussmann
- Joachim Beige (ORCID: https://orcid.org/0000-0002-1907-825X)
- Jana Breitfeld (ORCID: https://orcid.org/0000-0001-8346-8087)
- Anette Bachmann
- Berend Isermann (ORCID: https://orcid.org/0000-0003-0714-6160)
- Fabian Baalmann
- Péter Kovács (ORCID: https://orcid.org/0000-0002-0290-5423)
- Anke Tönjes
- Ronny Baber
- Luise Pirlich
Institutions
- Helmholtz Centre for Environmental Research (DE)
- Leipzig University of Applied Sciences (DE)
- Klinikum St. Georg (DE)
- Luther University (KR)
- Deutsches Herzzentrum der Charité (DE)
- University Hospital Leipzig (DE)
- KfH Kuratorium für Dialyse und Nierentransplantation (DE)
- Folkhälsans Forskningscentrum (FI)
- Martin Luther University Halle-Wittenberg (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1093/ndt/gfaf214
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00