βeta-2 glycoprotein I is a novel regulator of Apolipoprotein E containing HDL particles in females
Our findings identify β2GPI as a sex-specific regulator of HDL metabolism. In females, β2GPI modulates Apo E-containing HDL particles, influencing cholesterol distribution and lipoprotein composition. These results reveal a novel mechanism linking β2GPI to lipid homeostasis, with potential implications for cardiovascular risk in women with autoimmune disease. Targeting β2GPI-Apo E interactions may represent a therapeutic avenue for correcting dysregulated HDL metabolism in female-specific cardiometabolic and autoimmune contexts.
Authors
- Maaike Kockx (ORCID: https://orcid.org/0000-0003-0848-5930)
- Qi Miao
- Leonard Kritharides (ORCID: https://orcid.org/0000-0001-5818-8024)
- Ying Wang (ORCID: https://orcid.org/0000-0002-1444-5778)
- Bill Giannakopoulos (ORCID: https://orcid.org/0000-0002-7215-6683)
- James Weaver (ORCID: https://orcid.org/0000-0003-0755-5191)
- Liming Chen (ORCID: https://orcid.org/0000-0002-5682-2340)
- Steve Krilis
Institutions
- Concord Repatriation General Hospital (AU)
- St George Hospital (AU)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s13293-025-00766-9
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of New South Wales